In pregnancy, a fascinating interplay occurs between uterine commensal bacteria - your “Female Microbiome” or “Microbiota” - and maternal immune cells at the feto-maternal (baby-mother) interface. This captivating interaction unfolds through various distinct mechanisms, each playing a vital role in maintaining a healthy environment for both mother and baby.
Your friendly normal flora bacteria act as guardians, fortifying the physical barrier within the endometrium. They can alter the pH of the endometrial fluid, creating an environment that outcompetes pathogenic bacteria and they stimulate the production of antimicrobial peptides from endometrial cells, ensuring that harmful invaders are kept at bay. Additionally, these beneficial microbes preserve the integrity of epithelial tight junctions and promote stable mucus production, reinforcing the protective shield.
Additionally, the bacteria in the reproductive tract microbiome communicate with the endometrial cells, helping to regulate important processes like inflammation, hormone production, and cell differentiation. They also contribute to the regulation of the immune system facilitating a transition towards an anti-inflammatory, baby-friendly environment that can support pregnancy.
In addition to the beneficial bacteria, the reproductive tract microbiome also contains potentially harmful species. These bacteria can cause infection and inflammation, leading to problems such as endometritis and infertility. Chronic Endometritis (CE) is an often-silent condition which is characterized by a persistent inflammation of the uterine lining, and an abnormal endometrial microbiome. CE is usually devoid of any noticeable symptoms, leaving the afflicted patient unaware of its presence until it impacts their fertility.
Astonishingly, studies have revealed that more than 30% of women experiencing implantation failure and recurrent pregnancy loss have been found to have chronic endometritis.
The FERTILYSIS Female Microbiome tests can reveal active or chronic sub-clinical infections of the uterine lining (endometritis) and the female reproductive tract and other serious imbalances of your microbiome which can impair implantation and could lead to recurrent miscarriages, infertility and serious pregnancy complications. It is a mail-ordered, at-home testing method and it is performed using self-collected menstrual blood and vaginal swabs without requiring a biopsy.
SPECIMEN TYPE: Menstrual blood/plus two swabs for full panel
SAMPLE COLLECTION: Self collected
SAMPLE STORAGE & SHIPPING: Storage in the freezer. Shipping at ambient temperature.
RESULT TURNAROUND TIME: Depending on how busy the lab is, we estimate you will get your results within 10 business days from the day your sample reaches us *.
FERTILYSIS Female Microbiome: Full
|FERTILYSIS Female Microbiome: Vaginal
FERTILYSIS Couples Microbiome: Full
|FERTILYSIS Female Microbiome: Retest for Full
|FERTILYSIS Female Microbiome: Retest for Vaginal
|FastTrack Results SERVICE
* Please be advised that the turnaround time for specialized diagnostic tests is indicative and not guaranteed and may be extended due to a variety of factors, including but not limited to need for additional clinical evaluation of results, repeat of analysis in cases of unclear or ambiguous results and need for resampling in case of inadequate specimen quality. Therefore, the results will be available in the indicated timeframe as long as there are no additional overheads, as stated above, that may extend turnaround time.