If you are struggling with infertility and feel you haven’t been getting convincing answers, the Fertilysis Female microbiome is our 1st go-to test for unexplained infertility. It allows easy and early detection, diagnosis & treatment of Endometritis, Vaginitis & microbiome dysbiosis, all of which have been strongly associated with female reproductive system pathologies & infertility, RIF, RPL, chemical pregnancies and serious complications of the 2nd & 3rd trimesters.

The Role of a Healthy Baby-friendly Microbiome

A healthy pregnancy requires maintaining a "baby-friendly" uterine environment, achieved through an ideal microbiome dominated by beneficial Lactobacilli. These friendly normal bacteria act as guardians, fortifying the endometrial barrier, altering pH to prevent pathogens, and stimulating antimicrobial peptide production. They also preserve tight junction integrity, promote mucus production, and regulate essential processes like inflammation and hormone production.

A healthy microbiome contributes to immune system regulation, facilitating a transition towards an anti-inflammatory, baby-friendly environment that supports pregnancy.

The Abnormal (Dysbiotic) Microbiome

Medications, invasive medical procedures, hormonal treatments, or events such as pregnancy, miscarriage, or infection, may result in diminishment of the Lactobacilli population. The declining Lactobacilli population will leave open, unutilized space within the reproductive tract's ecosystem, allowing a diverse group of bacteria, referred to as "opportunistic pathogens," to take advantage and expand. These normally harmless bacteria can become pathogenic when they increase, resulting in an imbalance known as Dysbiosis, causing infection and inflammation, eventually leading to problems such as chronic endometritis and infertility.

Microbiome & Chronic endometritis (CE)

This silent condition involves persistent uterine inflammation due to bacterial pathogens and an abnormal Endometrial microbiome. It is extremely common to go completely without symptoms and for this reason, CE often remains underdiagnosed. It can make successful implantation challenging or even impossible, leading to implantation failure, chemical pregnancies, and recurrent miscarriage. Some uterine infections may even be directly toxic for the embryo or cause infections of the fetus and chorioamnionitis during later stages of pregnancy, with very serious, often devastative complications.

Α Dysbiotic uterus may cause a transition from an immunologically baby-friendly anti-inflammatory environment, towards a toxic, proinflammatory environment which can be hostile to the embryo, promoting the Th1 response. This dysregulation is characterized by production of proinflammatory cytokines such as interferon-gamma (IFN-γ), TNF-α and interleukin-2 (IL-2) and induces activation and proliferation of cytotoxic T cells and macrophages. Typically involved in defense against viral infections, intracellular bacteria, and tumors, a dysregulation of Th1 responses can contribute to autoimmune disease, chronic inflammation and immunologically-mediated pregnancy loss.